Have you tried Enso from Humanized yet?  Well, you should.  It is just about the greatest step forward for short cuts since, well, short cuts.  The premise is simple.  The software takes over your rarely used CapsLock key so that whenever you press it an innocuous promt appear over your desktop or on top of your open apps.  Enso is really two applications and I would recommend installing both, and both work by pressing the CapsLock.  So what does it do?  Alot, from launching apps via OPEN or OPEN WITH , to running calculations of highlighted text.  My personal favorite is the GOOGLE + keyword.  Two key clicks and I am browsing Google entries.  Fast easy and cool.  I am just touching the surface here and admittedly it does take a little getting used to but it will most certainly turn you from a power user to a super user in one click of the button.

http://www.humanized.com/enso/